Medicinal chemistry as a conduit for the modulation of quorum sensing

J Med Chem. 2010 Nov 11;53(21):7467-89. doi: 10.1021/jm901742e.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyl-Butyrolactones / chemistry
  • Acyl-Butyrolactones / metabolism
  • Acyl-Butyrolactones / pharmacology
  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Drug Discovery
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Homoserine / analogs & derivatives
  • Homoserine / chemistry
  • Homoserine / pharmacology
  • Homoserine / physiology
  • Humans
  • Lactones / chemistry
  • Lactones / pharmacology
  • Molecular Structure
  • Pentanes / chemistry
  • Pentanes / metabolism
  • Pentanes / pharmacology
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology
  • Peptides, Cyclic / physiology
  • Quorum Sensing / drug effects*
  • Structure-Activity Relationship

Substances

  • 4,5-dihydroxy-2,3-pentanedione
  • Acyl-Butyrolactones
  • Anti-Bacterial Agents
  • Lactones
  • N-octanoylhomoserine lactone
  • Pentanes
  • Peptides, Cyclic
  • Homoserine